Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Volume 1864, Issue 11, November 2018, Pages 3847-3858
Redox-active trace metal-induced release of high mobility group box 1(HMGB1) and inflammatory cytokines in fibroblast-like synovial cells is Toll-like receptor 4 (TLR4) dependent☆
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Graphical abstract
Abbreviations
RATM
redoxactive trace metals
RA
rheumatoid arthritis
FLS
fibroblast-like synovial cells
MRP8/14
myeloid-related protein 8/14
HMGB1
high mobility group box 1
iROS
intracellular reactive oxygen species
PPC
potassium peroxychromate
FC
flow cytometry
FM
fluorescence microscopy
DAMPs
damage associated molecular patterns
PAMPs
pathogen-associated molecular patterns
TLR4
Toll-like receptor 4
ELISA
enzyme-linked immunosorbent assay
LDH
Lactate Dehydrogenase
ANOVA
analysis of variance
Keywords
Fibroblast-like synovial cells
Redox active-trace metals
Rheumatoid arthritis
Oxidative stress
Inflammatory cytokines
Myeloid-related protein (MRP8/14)
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The project described was supported by Award Number DE021888 from the National Institute of Dental & Craniofacial Research to OJI. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Dental & Craniofacial Research of the US National Institutes of Health.
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AA performed these experiments as a partial fulfillment for a doctoral degree requirement.
© 2018 Published by Elsevier B.V.