Elsevier

Antiviral Research

Volume 71, Issues 2–3, September 2006, Pages 227-236
Antiviral Research

Mini-review
Polycyclic peptide and glycopeptide antibiotics and their derivatives as inhibitors of HIV entry

Dedicated to Professor Erik DeClercq on the occasion of reaching the status of Emeritus-Professor at the Katholieke Universiteit Leuven in September 2006.
https://doi.org/10.1016/j.antiviral.2006.04.008Get rights and content

Abstract

Antiviral activity and other biological properties of two groups of polycyclic peptides are discussed. Antibiotics of the complestatin–kistamycin group have a structural motif similar to that of the peptide core of antibacterial antibiotics of the vancomycin–teicoplanin group though no amino acid component in the chloropeptin–kistamicin antibiotics is identical to an amino acid incorporated in the peptide core of the antibiotics of the vancomycin–teicoplanin group. Chloropeptins and the hydrophobic several derivatives of antibacterial antibiotics are inhibitors of HIV and some other viruses. They interfere with the viral (i.e. HIV) entry process. Chemical modifications of natural glycopeptide antibiotics led to the compounds with antiviral properties whereas antibacterial properties were lost. These glycopeptide aglycons derivatives can be envisaged as potential lead compounds for application as microbicides against sexual HIV transmission.

Keywords

Complestatin
Kistamicin
Vancomycin
Eremomycin
Hydrophobic derivatives
Viral entry

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