Clinical research studyThe Association between Peripheral Artery and Lumbar Spine Disease: A Single-center Study
Section snippets
Methods
The institutional review board of Partners Healthcare and Massachusetts General Hospital approved the protocol.
All patients over age 18 years referred to the Vascular Diagnostic Laboratory at Massachusetts General Hospital for peripheral artery testing, which includes ABI determination, segmental limb pressures, and pulse volume recording (PVR) at rest and following treadmill exercise testing, from June 1, 2006 until May 31, 2009, were eligible for inclusion. The laboratory is accredited by the
Results
One hundred seven subjects (63 men, 58.9%) with mean age of 70 years (range 35-88 years) were included in the study. Exercise-induced peripheral artery disease was detected on noninvasive vascular tests in 38 patients (35.5%); lumbar spine disease was found in 81 patients (75.7%).
Table 1 shows the prevalence of lumbar spine degenerative disease among patients with exercise-induced peripheral artery disease (treadmill-positive) compared with those with a normal response to exercise
Discussion
Peripheral artery disease remains widely prevalent but under-diagnosed.1 The reasons for this may include lack of clinician awareness about peripheral artery disease, the various ways in which claudication may present, and the presence of coexisting illness, which may both mimic and mask symptoms of peripheral artery disease. One of the most common peripheral artery disease mimics is lumbosacral spine disease. In this study, we tested the hypothesis that peripheral artery disease and lumbar
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Funding: None.
Conflict of Interest: Michael R. Jaff is a noncompensated advisor for Abbott Vascular, Becker Venture Services Group, Cordis, Covidien, Medtronic Vascular, Equity Investment, PQ Bypass, Trireme, and Vascular Therapies; he is a Board Member, VIVA Physicians, a 501c3 not-for-profit research institute. All other authors have no potential conflicts of interest to disclose.
Authorship: All of the authors provided substantial contributions to the design of the study; the analysis and interpretation of the data; as well as writing the article.