Aortic Dilatation Associated With Bicuspid Aortic Valve: Relation to Sex, Hemodynamics, and Valve Morphology (the National Heart Lung and Blood Institute-Sponsored National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions)
Section snippets
Methods
The rationale and the design of the GenTAC registry have been previously described.18 In brief, GenTAC was established as a longitudinal observational cohort study of subjects with a genetically triggered thoracic aortic aneurysm. In 2006 to 2014, 3,763 participants were enrolled in the original 6 centers (Johns Hopkins University, Baylor College of Medicine, Oregon Health & Sciences University, University of Pennsylvania, University of Texas-Houston, and Weill-Cornell Medical College) and in 2
Results
Demographics, aortic dimensions, and hemodynamics in 259 males and in 80 females are compared in Table 1. The 2 groups were comparable in age, but males had a significantly higher average systolic blood pressure and body size than females. Annular diameters and both absolute diameters and Z scores of the SOV were significantly larger in males than females, whereas dimensions of the ascending aorta were comparable. Thirty-six percent of the patients had a dilated SOV (Z score ≥2) with a higher
Discussion
The GenTAC Registry provides an opportunity to examine aspects of BAV-associated aortopathy in a large, geographically diverse population of adults and children characterized using a standardized approach to phenotypic features and aortic imaging.18, 19 The population includes varying hemodynamic profiles of aortic valve function and many unoperated patients, and is representative of the ~3:1 male predominance noted in other large studies.
Although aortic enlargement is now well documented in
Disclosures
The authors have no conflicts of interest to disclose.
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See page 1174 for disclosure information.
The GenTAC Registry has been supported by US Federal Government contracts HHSN268200648199C and HHSN268201000048C from the National Heart Lung and Blood Institute and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland.