Preventive CardiologyFitness, Body Habitus, and the Risk of Incident Type 2 Diabetes Mellitus in Korean Men
Section snippets
Methods
Our study participants included 5,616 men who participated in 2 general health examinations from 1998 to 2009 at the Samsung Medical Center, Seoul, South Korea. Of these participants, men who had hypertension, T2DM, or a history of cardiovascular disease and those who were taking antihypertensive medications and/or oral hypoglycemic agents at baseline were excluded. Further exclusions included subjects whose relevant blood markers (glucose and glycated hemoglobin A1c) and CRF, determined during
Results
During a median follow-up of 5 years, 170 of the 3,770 men (4.5%) developed T2DM. Men who developed T2DM had greater age, BMI, alcohol consumption, glucose, triglycerides, and glycosylated hemoglobin (HbA1c) levels but lower HDL cholesterol and VO2peak (all p <0.05) at baseline compared with men who remained nondiabetics (Table 1). Table 2 summarizes the relative risks (RR) and 95% confidence interval (CI) of incident T2DM with specific reference to CRF and obesity. After adjusting for age and
Discussion
Our findings indicate that CRF and obesity were associated with a lower and higher risk of incident T2DM, respectively, and that these associations were mutually dependent. Thus, both improved fitness and reduction of body weight and fat stores should be encouraged to reduce the risk of developing diabetes. However, the novel finding from our study is that obese, unfit men had greater risk of incident T2DM compared with normal weight, fit men, whereas obese, fit men had a similar risk of
Disclosures
The authors have no conflicts of interest to declare.
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Cited by (22)
2023 update: The importance of cardiorespiratory fitness in the United States
2024, Progress in Cardiovascular DiseasesIndependent and joint associations of non-exercise cardiorespiratory fitness and obesity with risk of type 2 diabetes mellitus in the Rural Chinese Cohort Study
2022, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :As well, this study used a large-sample representative cohort, a prospective design, and a standardized measurement of obesity exposure. Previous studies examining diabetes incidence, obesity, and fitness have recruited from fitness clinics or from health screening settings with less representative cohort samples [21,42]. Finally, the sensitivity analysis that excluded participants with IFG at baseline showed the robustness of the results.
Get Moving: Physical Activity and Exercise for Mental Health
2019, A Clinical Introduction to Psychosis: Foundations for Clinical Psychologists and NeuropsychologistsCardiorespiratory fitness, fatness and incident diabetes
2017, Diabetes Research and Clinical PracticeCitation Excerpt :Cardiorespiratory fitness (CRF) expresses the maximal capacity of the cardiorespiratory system to take up and use oxygen during exercise [8], and is negatively associated with diabetes incidence [9–15]. The impact of fitness on the association between fatness and diabetes is controversial [15]. Several studies have indicated that the effect of CRF on diabetes incidence depends on the level of fatness [11,12,15–17].
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