ReviewUsefulness of Circulating Biomarkers for the Prediction of Left Ventricular Remodeling After Myocardial Infarction
Section snippets
Methods
We conducted a computerized Medline search of published articles through November 2011. We searched for “ventricular remodeling AND myocardial infarction,” “ventricular remodeling AND biomarkers,” and “myocardial infarction AND heart failure AND biomarkers.” Bibliographies of all relevant articles were searched manually for additional articles. Next, we performed a computerized search of the Journal Citation Reports through November 2011 to retrieve all articles citing any of the articles
Results
We selected and reviewed 59 publications. Three were published from 1996 to 2000, 13 from 2001 to 2005, and 43 from 2006 through 2011. Table 1 presents data about the relation between biomarkers and LV remodeling. In all, these studies examined 112 relations between 52 different biomarkers and LV remodeling. A positive correlation between biomarker levels and LV remodeling was reported in 63% of cases, a negative correlation was reported in 4%, and no correlation in 33%. Several candidate
Discussion
This systematic overview shows that a relatively large number of potential biomarkers have been studied in relation to LV remodeling after MI. Although several have been repeatedly studied in independent cohorts, many candidates have been analyzed only in single studies, and it is thus more difficult to generalize their results. Moreover, it must be recognized that most studies were of relatively small size; as presented in Table 1, the associations were often tested in cohorts with <100
Acknowledgment
We thank Jo Ann Cahn for improving the English-language report.
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Cited by (0)
This work was supported by Grant ANR-11-EMMA-029-01 from ANR, Paris, France. Dr. Fertin was a recipient of a Fédération Francaise de Cardiologie, Paris, France/Société Francaise de Cardiologie, Paris, France fellowship.