Original articleClinical Significance of Owl Eye Morphologic Features by In Vivo Laser Confocal Microscopy in Patients With Cytomegalovirus Corneal Endotheliitis
Section snippets
Methods
The study population consisted of 6 eyes of 6 consecutive patients (6 men; mean, 73.3 years), whose active CMV corneal endotheliitis was diagnosed and treated between April 2010 and March 2011 at the Department of Ophthalmology, Kanazawa University Hospital, Kanazawa, Japan (Patients 1 through 5), or the Department of Ophthalmology, Fukui-ken Saiseikai Hospital, Fukui, Japan (Patient 6; Table). The clinical diagnosis was performed based on slit-lamp findings of active corneal endotheliitis
Clinical Manifestations
The Table summarizes the clinical manifestations for 6 eyes of 6 patients. The mean follow-up period for all patients was 4.2 ± 2.5 months (range, 1 to 8 months). All patients were male (6/6; 100%) and had long histories (more than 2 years) of anterior uveitis (6/6; 100%) and IOP elevation of unknown origin (6/6; 100%) that was treated by corticosteroids and antiglaucoma agents (duration, 24 to 144 months; mean ± standard deviation, 84.0 ± 41.6 months). All patients had corneal edema (6/6;
Discussion
Herein, we report the clinical manifestations together with detailed in vivo laser confocal microscopic findings of all corneal cell layers in 6 Japanese patients with PCR-proven CMV corneal endotheliitis. To the best of the authors' knowledge, this is the largest series of confocal microscopic analyses of CMV corneal endotheliitis. The main highlight of the case series is the supportive diagnostic value of owl eye morphologic features by confocal microscopy. Most notably, we found that these
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