Original articleAutologous Translocation of the Choroid and Retinal Pigment Epithelium in Age-related Macular Degeneration
Section snippets
Methods
Patients with either subfoveal lesions or geographic atrophy that was the result of AMD were included. After subretinal extraction of the neovascular complex, an autologous peripheral full-thickness explant of RPE, Bruch membrane, and choroid was translocated from the midperiphery to the macula. Surgery was completed with gas or silicone-oil tamponade (Figure 1S and Supplementary Video). In patients with severe cataract,37 phacoemulsification was performed at the time of silicone oil removal.
Results
From March 2004 to December 2004, a total of 43 patients (45 eyes) were enrolled onto the study. Twenty-five patients were women and 18 were men. The mean age was 76 ± nine years. Out of the 45 eyes, five eyes were missed at the three-month follow-up, and five eyes were missed at the six-month follow-up. Among the five patients who missed the six-month examination, four were examined at three months. All patients had visual loss due to AMD. Five eyes with classic membranes, 14 with occult
Discussion
In the current study, we report the six-month follow-up of 45 eyes after patch translocation. The study, which follows up on small case series,35, 36, 45 is, to our knowledge, the first prospective functional and anatomical evaluation of an autologous free graft of RPE and choroid using a technique that might be less prone to PVR compared with the 360° macular rotation in a larger group of patients with AMD. In the long term, patch translocation reduced the chance of visual loss of 15 letters
Antonia M. Joussen, MD, is a consultant vitreo-retinal surgeon at the Center of Ophthalmology, Cologne, Germany. Besides the clinical work, Dr Joussen heads a basic science laboratory with main focus on angiogenesis. After medical school in Bochum, Vienna, and Heidelberg, Dr Joussen received her clinical ophthalmology training at the Universities of Heidelberg and Aachen. From 1999–2001, she carried out a research-fellowship on diabetic retinopathy in Anthony Adamis′s Laboratory at Childrens
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Cited by (0)
Antonia M. Joussen, MD, is a consultant vitreo-retinal surgeon at the Center of Ophthalmology, Cologne, Germany. Besides the clinical work, Dr Joussen heads a basic science laboratory with main focus on angiogenesis. After medical school in Bochum, Vienna, and Heidelberg, Dr Joussen received her clinical ophthalmology training at the Universities of Heidelberg and Aachen. From 1999–2001, she carried out a research-fellowship on diabetic retinopathy in Anthony Adamis′s Laboratory at Childrens Hospital, Harvard Medical School, Boston, Massachusetts.
Supported in part by the Deutsche Forschungsgemeinschaft (DFG) Jo 324/6-1 und 6-2 (Emmy Noether), Jo 324/4-1, and Ki 743/5-1, and Ki 743/2-1. The Brunnenbusch Stein Stiftung and the Glaser Stiftung sponsored patient related costs and the RetinoVit Stiftung Köln was helpful in funding necessary equipment.
Supplemental Material and Video available at AJO.com.