Elsevier

Advances in Medical Sciences

Volume 63, Issue 2, September 2018, Pages 353-358
Advances in Medical Sciences

Original research article
Effect of maternal weight during pregnancy on offspring muscle strength response to resistance training in late adulthood

https://doi.org/10.1016/j.advms.2018.07.001Get rights and content

Abstract

Purpose

Maternal obesity can unfavorably influence offspring body composition, muscle strength, and possibly muscle’s adaptability to training, but the human studies are scarce. Therefore, we aimed to investigate the effect of maternal obesity on offspring muscle strength responses to resistance training intervention in elderly frail women.

Materials/methods

Recruited participants were elderly frail women offspring of lean/normal weight mothers (n = 19, mean body mass index (BMI): 22.8 kg/m2, range: 19.9–24.5) or overweight/obese mothers (n = 16, mean BMI: 29.7 kg/m2, range: 28.2–34.2). Information on maternal BMI immediately prior to delivery was collected from the birth registers. All women participated in a 4-month supervised progressive resistance training intervention three times a week for 60 min. Predicted 1-RM of abdominal crunch, hip abduction, leg curl, leg press, seated row, and total strength were measured at baseline and after each month of training.

Results

According to rANOVA, strength increased significantly in both groups (p for time <0.001), but no significant between the group difference were detected (p for time x group interaction > 0.072). On average, muscle strength of the women offspring of overweight/obese mothers tended to be lower than in women offspring of lean/normal weight mothers, but the only significant difference was found in leg curl (p = 0.006). No significant differences between the groups were found in relative strength changes from baseline to 4-months.

Conclusions

Muscle strength response to supervised resistance training is not modulated by maternal adiposity in late pregnancy in elderly frail female offspring.

Introduction

The Developmental Origins of Health and Disease (DOHaD) hypothesis proposes that environmental exposures during sensitive periods of development can result in phenotypic alterations affecting later health and disease susceptibility [1]. The prenatal period is associated with rapid cell division and is one of the most sensitive time periods in relation to developmental programming. In fact, recent evidence suggests that maternal adiposity during pregnancy can hamper offspring’s skeletal muscle development [2] and increase the long-term risk for obesity, cardiovascular disease, type 2 diabetes [[3], [4], [5]].

Key stages of skeletal muscle development occur during early embryonic stage, mid pregnancy, and postnatally [[6], [7], [8]]. Especially, the mid gestational period can have long-term consequences to offspring muscle strength and function [9]. During this period, the maternal obesity-induced inflammation can drive the differentiation of mesenchymal stem cells (MSCs) into adipocytes rather than myocytes [10]. Maternal obesogenic environment can also increase intramyocellural fat accumulation in offspring, decrease skeletal muscle cross-sectional area [11], and muscle strength [12]. Although the exact mechanisms that explain the effect of maternal obesity and/or obesogenic environment on offspring muscle strength are unknown, the maternal obesity-induced inflammation could play a role. According to previous evidence, maternal obesity can decrease myogenesis by up-regulating inflammatory IKK/NF-B signaling pathway and subsequently inhibiting Wnt/β-catenin signaling pathway [13]. β-catenin can have a critical role in the growth of adult’s skeletal muscles after mechanical overload [14,15].

Interestingly, in human studies, maternal obesity has also been associated with increased concentration of inflammatory markers, e.g. interleukin-6 and C-reactive protein, in the cord blood [16]. Furthermore, in some human studies, but not in all [4], exposure to maternal adiposity has been associated with decreased fat free mass and increased fat mass in offspring [17,18]. This can lead into accumulation of intramuscular fat, which has been associated with decreased walking speed and grip strength in the elderly subjects [19]. Due to the link between the maternal obesity, inflammation and β-catenin, we hypothesized that elderly frail women offspring of overweight or obese mothers (OOM) can have compromised muscle strength response to resistance training compared to elderly frail women offspring of lean/normal weight mothers (OLM). Therefore, the purpose of this study was to compare the muscle strength changes between elderly frail women OLM and OOM after a 4-month supervised resistance training.

Section snippets

Participants

Thirty-five elderly frail women (age 72.3 ± 3.2 years) from the clinical Helsinki Birth Cohort Study (HBCS) (n = 2003) were recruited for this study. Only women were recruited as the main aim of this study project was to investigate the association between risk factors of type 2 diabetes (e.g. insulin resistance) and the ageing process specifically in frail women. Recruited women were either offspring of mothers who belonged to the lowest body mass index (BMI) quartile (BMI ≤ 26.3 kg/m2,

Baseline characteristics

Baseline characteristics are shown in Table 1. There were no statistically significant differences in anthropometrics, physical capacity or performance between the OLM or OOM. As expected maternal BMI was significantly higher in the OOM group than in the OLM group.

Adherence to training and LTPA

There were no statistically significant differences between the groups in adherence to supervised resistance training program (Table 2). Subjects participated on average in 78.6% of all training sessions. We found no statistically

Discussion

We hypothesized that OOM would respond differently to 4-months of resistance training. However, the findings from the study do not support this hypothesis. It was actually discovered that muscle strength gains during the intervention were similar in the OLM and the OOM groups. In both groups, a clear increase in muscle strength was detected. Albeit, in the OOM group the average muscle strength values seemed to be lower, but they were non-significant, except for leg curl. In leg curl we detected

Conclusion

Maternal overweight/obesity had no influence on the offspring muscle strength adaptability to resistance training intervention. Based on the present findings, elderly frail women offspring of either lean/normal weight mothers or overweight/obese mothers had similar strength gain during the 4-month supervised resistance training intervention. These data provide additional support that elderly frail women offspring of overweight/obese women may have lower muscle strength, but it may be muscle

Author contribution

Study Design: Minna K Salonen, Samuel Sandboge, Johan Eriksson,

Data Collection: Liisa Penttinen, Mika Simonen

Statistical Analysis: Niko S Wasenius

Data Interpretation: Niko S Wasenius, Mika Simonen, Minna Salonen, Johan Eriksson

Manuscript Preparation: Niko Wasenius, Mika Simonen, Minna Salonen, Liisa Penttinen, Samuel Sandboge, Johan Eriksson

Literature Search: Niko Wasenius, Mika Simonen, Minna Salonen, Liisa Penttinen

Funds Collection: Johan G Eriksson, Minna K Salonen

Financial disclosure

HBCS has been supported by grants from Finska Läkaresällskapet, the Finnish Special Governmental Subsidy for Health Sciences, Academy of Finland, Samfundet Folkhälsan, Liv och Hälsa, the Signe and Ane Gyllenberg Foundation, and EU FP7 (DORIAN) project number 278603. EU H2020-PHC-2014-DynaHealth Grant no. 633595. The funding source had no role in study design, collection or interpretation of the data, analysis, or publishing of the study.

Conflict of interests

The authors declare no conflict of interests

Acknowledgements

The authors would like to thank physiotherapist Minna Lipasti for her excellent assistance with research.

References (37)

  • N.B. Romero et al.

    Main steps of skeletal muscle development in the human: morphological analysis and ultrastructural characteristics of developing human muscle

    Handb Clin Neurol

    (2013)
  • L.D. Brown et al.

    Impact of placental insufficiency on fetal skeletal muscle growth

    Mol Cell Endocrinol

    (2016)
  • D.J. Barker

    The origins of the developmental origins theory

    J Intern Med

    (2007)
  • S.A. Bayol et al.

    Growing healthy muscles to optimise metabolic health into adult life

    J Dev Orig Health Dis

    (2014)
  • R.M. Reynolds et al.

    Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years

    BMJ

    (2013)
  • J.G. Eriksson et al.

    Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki birth cohort study (HBCS)

    Ann Med

    (2015)
  • J.G. Eriksson et al.

    Long-term consequences of maternal overweight in pregnancy on offspring later health: findings from the Helsinki birth cohort study

    Ann Med

    (2014)
  • M. Du et al.

    Fetal programming of skeletal muscle development in ruminant animals

    J Anim Sci

    (2010)
  • X. Yan et al.

    Developmental programming of fetal skeletal muscle and adipose tissue development

    J Genomics

    (2013)
  • M. Du et al.

    Maternal obesity, inflammation, and fetal skeletal muscle development

    Biol Reprod

    (2010)
  • S.A. Bayol et al.

    A maternal cafeteria diet during gestation and lactation promotes adiposity and impairs skeletal muscle development and metabolism in rat offspring at weaning

    J Physiol (Paris)

    (2005)
  • S.A. Bayol et al.

    Evidence that a maternal "junk food" diet during pregnancy and lactation can reduce muscle force in offspring

    Eur J Nutr

    (2009)
  • J.F. Tong et al.

    Maternal obesity downregulates myogenesis and beta-catenin signaling in fetal skeletal muscle

    Am J Physiol Endocrinol Metab

    (2009)
  • D.D. Armstrong et al.

    Expression of beta-catenin is necessary for physiological growth of adult skeletal muscle

    Am J Physiol, Cell Physiol

    (2006)
  • D.D. Armstrong et al.

    Wnt/beta-catenin signaling activates growth-control genes during overload-induced skeletal muscle hypertrophy

    Am J Physiol, Cell Physiol

    (2005)
  • P.M. Catalano et al.

    Fetuses of obese mothers develop insulin resistance in utero

    Diabetes Care

    (2009)
  • N.C. Harvey et al.

    Parental determinants of neonatal body composition

    J Clin Endocrinol Metab

    (2007)
  • H.R. Hull et al.

    Impact of maternal body mass index on neonate birthweight and body composition

    Am J Obstet Gynecol

    (2008)
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