Original InvestigationReliability of Total Renal Volume Computation in Polycystic Kidney Disease From Magnetic Resonance Imaging
Section snippets
Patients and Imaging Acquisition
A cohort of 30 ADPKD patients (23 patients with normal renal function and seven patients with chronic kidney disease) aged 26–72 years (45 ± 12 years) were enrolled and underwent the MRI study. In all patients, ADPKD had been previously diagnosed with echographic investigation and based on Ravine criteria (16).
MRI data were acquired using a 1.5T scanner (Intera Achieva; Philips Medical System). The imaging protocol included unenhanced sequences only.
T2-weighted turbo spin-echo sequences with
Results
The automated method was successfully applied to all MR images in all patients. Thirteen of them had exophytic cysts for a total count of 43 cysts. In some acquired slices, the cysts were completely detached from the kidney, and the inclusion in the kidney volume of these sections was not possible using the proposed method.
Two examples of the detected contours in two patients from coronal and axial acquisitions are shown in Figure 3a. Examples of the segmentation result in one slice for one
Discussion and conclusions
More than 4 million people are affected by ADPKD worldwide, and currently, very few conclusive treatments are available to slow or prevent the disease that leads to ESRD in most patients. TRV is currently considered an important index to monitor the disease progression, and its assessment is mandatory for targeting therapeutic trials in patients with ADPKD. Up to now, the assessment of TRV has been performed from CT or MR scans by manually tracing renal contours. The proposed technique overcame
Acknowledgments
The authors thank Dott. Enrico Cavagna, Radiology Department of the Infermi Hospital, Rimini, Italy, for data acquisition and the Cassa di Risparmio di Cesena Foundation for supporting D.T. in this research.
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