Chapter 6 - Antipsychotic Drugs
Section snippets
Comparative Studies
A 12-month, randomised study of aripiprazole, quetiapine and ziprasidone in first-episode patients (FEP) reported a discontinuation rate of 16.3% due to adverse events (AEs) [1C]; the most common AEs were weight gain, fatigue and sedation.
In a randomised, controlled study of aripiprazole vs. risperidone in acute bipolar mania (n = 50) the most common AE was headache (risperidone, n = 2; aripiprazole, n = 1) [2C].
A randomised, controlled study of clozapine vs. ziprasidone in schizophrenia and cannabis
Observational Studies
Full-dose amisulpride was compared to a combination of low-dose amisulpride and low-dose sulpiride in combination [74c]. There were no significant between-group differences and no patient had a QTc interval > 500 ms; prolactin levels were increased particularly in females.
Controlled Studies
A randomised, double-blind, dose-finding study (n = 215) investigating amisulpride in postoperative nausea and vomiting (PONV) prophylaxis found no difference to placebo at all doses [75c]. There were no significant CNS or cardiac
Acknowledgements
The authors thank Sam Joshva for his editorial assistance.
References (233)
- et al.
Aripiprazole, ziprasidone and quetiapine in the treatment of first-episode nonaffective psychosis: a 12-week randomized, flexible-dose, open-label trial
Schizophr Res
(2013) - et al.
Is the combination of a mood stabilizer plus an antipsychotic more effective than mono-therapies in long-term treatment of bipolar disorder? A systematic review
J Affect Disord
(2014) - et al.
Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis
Lancet
(2013) - et al.
Antipsychotic-drug-induced hyperprolactinemia: physiopathology, clinical features and guidance
Encéphale
(2014) - et al.
ECG parameters in children and adolescents treated with aripiprazole and risperidone
Prog Neuropsychopharmacol Biol Psychiatry
(2014) - et al.
Comparison of metabolic effects of aripiprazole, quetiapine and ziprasidone after 12 weeks of treatment in first treated episode of psychosis
Schizophr Res
(2014) - et al.
Canadian Network for Observational Drug Effect Studies (CNODES) Investigators. Atypical antipsychotics and hyperglycemic emergencies: multicentre, retrospective cohort study of administrative data
Schizophr Res
(2014) - et al.
No evidence for a role of the peroxisome proliferator-activated receptor gamma (PPARG) and adiponectin (ADIPOQ) genes in antipsychotic-induced weight gain
Psychiatry Res
(2014) - et al.
Pharmacogenetics of adverse events in schizophrenia treatment: comparison study of ziprasidone, olanzapine and perazine
Psychiatry Res
(2014) - et al.
Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances
J Psychiatr Res
(2014)
APD421 (amisulpride) prevents postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled, multicentre trial
Br J Anaesth
Efficacy and of aripiprazole in Chinese Han schizophrenia subjects: a randomized, double-blind, active parallel-controlled, multicenter clinical trial
Schizophr Res
Aripiprazole: a new risk factor for pathological gambling? A report of 8 case reports
Addict Behav
Hypersexuality associated with aripiprazole: a new case and review of the literature
Therapie
Comparison of the effectiveness of aripiprazole and risperidone for the treatment of acute bipolar mania
J Res Med Sci
Ziprasidone versus clozapine in the treatment of dually diagnosed (DD) patients with schizophrenia and cannabis use disorders: a randomised study
Am J Addict
Aripiprazole versus risperidone for treating children and adolescents with tic disorder: a randomized double blind clinical trial
Child Psychiatry Hum Dev
Quality of life in patients with schizophrenia: the impact of socio-economic factors and adverse effects of atypical antipsychotics drugs
Psychiatr Q
Metabolic alterations associated with first and second generation antipsychotics: a twenty-years open study
Psychiatr Danub
Identification and management of adverse effects of antipsychotics in a tertiary care teaching hospital
J Res Pharm Pract
Antipsychotics for delirium in the general hospital setting in consecutive 2453 inpatients: a prospective observational study
Int J Geriatr Psychiatry
Early nonresponse determined by the clinical global impressions scale predicts poorer outcomes in youth with schizophrenia spectrum disorders naturalistically treated with second-generation antipsychotics
J Child Adolesc Psychopharmacol
Twenty-four months of antipsychotic treatment in children and adolescents with first psychotic episode: discontinuation and tolerability
J Clin Psychopharmacol
Atypical antipsychotic poisoning in young children: a multicentre analysis of poisons centres data
Eur J Pediatr
Aripiprazole versus haloperidol in combination with clozapine for treatment-resistant schizophrenia: a 12-month, randomized, naturalistic trial
J Clin Psychopharmacol
Comparison of droperidol and haloperidol for use by paramedics: assessment of safety and effectiveness
Prehosp Emerg Care J
A prospective study of high dose sedation for rapid tranquilisation of acute behavioural disturbance in an acute mental health unit
BMC Psychiatry
A naturalistic comparison study of the efficacy and safety of intramuscular olanzapine, intramuscular haloperidol, and intramuscular levomepromazine in acute agitated patients with schizophrenia
Hum Psychopharmacol
Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: a comparison of efficacy, safety, and side effects
Palliat Support Care
Trends in quetiapine use and non-fatal quetiapine-related ambulance attendances
Drug Alcohol Rev
Atypical antipsychotics for psychosis in adolescents
Cochrane Database Syst Rev
Evidence base for using atypical antipsychotics for psychosis in adolescents
Schizophr Bull
Almost all antipsychotics result in weight gain: a meta-analysis
PLoS One
Meta-analysis on the efficacy and tolerability of the augmentation of antidepressants with atypical antipsychotics in patients with major depressive disorder
Braz J Med Biol Res
The effects of novel and newly approved antipsychotics on serum prolactin levels: a comprehensive review
CNS Drugs
Antipsychotic drugs and safety concerns for breast-feeding infants
South Med J
Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis
Int J Neuropsychopharmacol
Antipsychotics for primary alcohol dependence: a systematic review and meta-analysis of placebo-controlled trials
J Clin Psychiatry
A review of the pharmacology, efficacy and tolerability of recently approved and upcoming oral antipsychotics: an evidence-based medicine approach
CNS Drugs
The comparative efficacy of intramuscular antipsychotics for the management of acute agitation
Australas Psychiatry
Atypical antipsychotics in the treatment of children and adolescents with pervasive developmental disorders
Psychopharmacology (Berl)
Second generation antipsychotics in Asperger's Disorder and high functioning autism: a systematic review of the literature and effectiveness of meta-analysis
Curr Clin Pharmacol
Weight gain and increase of body mass index among children and adolescents treated with antipsychotics: a critical review
Eur Child Adolesc Psychiatry
Atypical antipsychotics in the treatment of delirium
Psychiatry Clin Neurosci
Role of atypical antipsychotics in the treatment of generalized anxiety disorder
CNS Drugs
Antipsychotic induced weight gain: genetics, epigenetics, and biomarkers reviewed
Curr Psychiatry Rep
Incidence of cardiovascular outcomes and diabetes mellitus among users of second-generation antipsychotics
J Clin Psychiatry
Risk of ischemic stroke with the use of risperidone, quetiapine and olanzapine in elderly patients: a-based, case-crossover study
J Psychopharmacol
Antipsychotics and associated risk of out-of-hospital cardiac arrest
Clin Pharmacol Ther
The explanatory role of stroke as a mediator of the mortality risk difference between older adults who initiate first- versus second-generation antipsychotic drugs
Am J Epidemiol
Cited by (1)
Antipsychotic Drugs
2018, Side Effects of Drugs AnnualCitation Excerpt :Additional case studies can be found in these reviews [280R,281R,282R].