Review article
The integrated processes of hard tissue regeneration with special emphasis on fracture healing

https://doi.org/10.1016/S1079-2104(96)80431-8Get rights and content

When bone is fractured, a sequence of dynamic events ensue to restore form and therefore function. Many key biologic cell regulators for these events have been identified, expressed through recombinant technology, and their roles posited. Moreover, the availability of recombinantly engineered molecules, such as the bone morphogenetic proteins with their potential to benefit patient care, has ushered in an important era in clinical dentistry that may eliminate either autografting or bank bone allografts. Therefore, in this review article, we have highlighted some of the exciting biologic regulators relevant to bone fracture healing and outlined the dynamic elements in this process.

References (87)

  • SteenfosHH

    Growth factors and wound healing

    Scand J Plast Reconstr Hand Surg

    (1994)
  • GoldringMB et al.

    Skeletal tissue response to cytokines

    Clin Orthop Rel Res

    (1990)
  • RobinsonCJ

    Growth factors: therapeutic advances in wound healing

    Ann Med

    (1993)
  • MassaguéJ

    The transforming growth factor-beta family

    Annu Rev Cell Biol

    (1990)
  • CentrellaM et al.

    Current concepts review: Transforming growth factor beta and remodeling of bone

    J Bone Joint Surg Am

    (1991)
  • SpornMB et al.

    TGFß: Problems and prospects

    Cell Regulation

    (1990)
  • BolanderME

    Regulation of fracture repair by growth factors

    Proc Soc Exp Biol Med

    (1992)
  • EinhornTA

    Enhancement of fracture healing by molecular or physical means; an overview

  • EinhornT

    Current concepts review: enhancement of fracture healing

    J Bone Joint Surg Am

    (1995)
  • EinhornTA et al.

    The expression of cytokine activity by fracture callus

    J Bone Miner Res

    (1995)
  • BonewaldLF et al.

    Role of transforming growth factor-beta in bone remodeling

    Clin Orthop

    (1989)
  • MundyGR

    Cytokines and growth factors in the regulation of bone remodeling

    J Bone Miner Res

    (1993)
  • KingsleyDM

    The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

    Genes Dev

    (1994)
  • BeckLS et al.

    In vivo induction of bone by recombinant human transforming growth factor beta 1

    J Bone Miner Res

    (1991)
  • McKinney L, Hollinger JO. A bone regeneration study: Transforming growth factor-β1 and its delivery. J Craniofac Surg...
  • RipamontiU et al.

    Bone morphogenetic proteins: from developmental biology to molecular therapeutics

    S Afr J Sci

    (1995)
  • HollingerJO

    Factors for osseous repair and delivery: part 1

    J Craniofac Surg

    (1993)
  • HollingerJO

    Factors for osseous repair and delivery: part 11

    J Craniofac Surg

    (1993)
  • Hollinger JO, Leong K. Poly(α-hydroxy acids): carriers for bone morphogenetic proteins. Biomaterials (in...
  • LandesmanR et al.

    In vivo analysis of the half-life of the osteoinductive potential of demineralized bone matrix using diffusion chambers

    Calcif Tissue Int

    (1989)
  • MardenL et al.

    Temporal changes during bone formation the calvarium induced by osteogenin

    Calcif Tissue Int

    (1993)
  • NakaseT et al.

    Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing

    J Bone Miner Res

    (1994)
  • BostromMG et al.

    Immunolocalization and expression of bone morphogenetic proteins 2 and 4 in fracture healing

    J Orthop Res

    (1995)
  • CareyD et al.

    Expression of bone morphogenetic protein-6 messenger RNA in bovine growth plate chondrocytes of different size

    J Bone Miner Res

    (1995)
  • YoshikawaH et al.

    Prognostic significance of bone morphogenetic activity in osteosarcoma tissue

    Cancer

    (1988)
  • YoshikawaH et al.

    Expression of bone morphogenetic proteins in human osteosarcoma: immunohistochemical detection with monoclonal antibody

    Cancer

    (1994)
  • YoshikawaH et al.

    Clinical significance of bone morphogenetic activity in osteosarcomas: a study of 20 cases

    Cancer

    (1985)
  • WozneyJM

    The bone morphogenetic protein family and osteogenesis

    Mol Reprod Dev

    (1992)
  • CentrellaM et al.

    Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone

    J Clin Invest

    (1992)
  • RobsonMC et al.

    Platelet derived growth factor BB for treatment of chronic pressure ulcers

    Lancet

    (1992)
  • TrippelS et al.

    Interaction of basic fibroblast growth factor with bovine growth plate chondrocytes

    J Orthop Res

    (1992)
  • McKibbinB

    The biology of fracture healing in long bones

    J Bone Joint Surg Br

    (1978)
  • BorderWA et al.

    Transforming growth factor beta in tissue fibrosis

    N Eng J Med

    (1994)
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