Original contributionCellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease
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Regenerative nanomedicine applications for neurodegenerative diseases of central nervous system
2020, Theory and Applications of Nonparenteral NanomedicinesThe role of growth factors as a therapeutic approach to demyelinating disease
2016, Experimental NeurologyNano and microcarriers to improve stem cell behaviour for neuroregenerative medicine strategies: Application to Huntington's disease
2016, BiomaterialsCitation Excerpt :Transplanted stem and progenitor cells can promote the survival of host cells by releasing neuroprotective trophic factors. In addition, many studies have demonstrated the preclinical feasibility of encapsulation as a means of delivering factors to the CNS, and more particularly, genetically engineered cells secreting trophic factors for HD [145]. In general, these studies demonstrate that encapsulated cells can be protected and remain viable for extended periods of time to produce significant neuroprotective and behavioural benefits.
Encapsulated cell therapy for neurodegenerative diseases: From promise to product
2014, Advanced Drug Delivery ReviewsThe CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model
2013, Neuroscience LettersCitation Excerpt :The ciliary neurotrophic factor (CNTF) possesses various beneficial effects demonstrated in experimental models and clinical trials. It proved to promote neurite outgrowth, ameliorate learning and memory deficits, enhance glial glutamate uptake and thereby protect from excitotoxic cell damage [1–3,6,7,9,11]. Considering that neuronal plasticity and network reorganization as well as neuronal cell loss characterize the process of epilepsy development following an initial brain injury [12,15], treatment with CNTF might be an attractive prophylactic compound to interfere with epileptogenesis.