Trends in Cell Biology
ForumThe visual display of regulatory information and networks
Section snippets
Principles and advantages
The main principles and advantages of this mode of representation are:
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its simplicity (compare the four representations in Fig. 2);
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the distinction between chemical transformation or transport and regulatory information (i.e. control);
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the distinction between immediate direct effects on the activity of the protein and delayed effects on protein content. Mechanisms of the first type take place in seconds and minutes, whereas those of the second type require longer delays (in the case of
Concluding remarks
We believe that the use of such schemes to summarize experimental findings on signal transduction would be very useful. By using simple logic, they permit easy verification of whether the data presented support the scheme proposed and which possible validations and controls are missing. In a positive cascade, for instance, any increase of a positive control should increase the final effect, and any decrease of such a control should decrease the final effect. It is also easy to forget or
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