Lead discovery of α,β-Unsaturated sulfones from a combinatorial library as inhibitors of inducible VCAM-1 expression
α,β-Unsaturated sulfones have been discovered from a combinatorial library as leads for a new series of inhibitors of inducible VCAM-1 expression.
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Acknowledgements
We would like to thank Drs. J. Sikorski and W. D. Weingarten for fruitful discussions and critical proofreading of the manuscript of this publication.
References (13)
Cell
(1994)J. Allergy Clin. Immunol.
(1996)N. Engl. J. Med.
(1990)- et al.
Annu. Rev. Immunol.
(1990) - et al.
Annu. Rev. Immunol.
(1990) - et al.
Annu. Rev. Med.
(1994)
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