Targeting radiosensitizers to DNA by minor groove binding: nitroarenes based on netropsin and distamycin
The compounds bind strongly to DNA, even when n = 1. This finding is of relevance to other chemotherapeutic agents acting on DNA, even though radiosensitization is not enhanced by targeting in this way.
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Cited by (7)
Molecular dynamics of d(CGCGAATTCGCG)<inf>2</inf> complexed with netropsin and its minor groove methylating analog, Me-lex, using explicit and implicit water models
2009, Journal of Molecular Structure: THEOCHEMChemical Radiosensitizers for Use in Radiotherapy
2007, Clinical OncologyCitation Excerpt :The topic of DNA targeted radiosensitizing drugs has attracted attention [101]. Examples include nitroimidazole/intercalator conjugates [102,103], nitroacridines (e.g. nitracrine*) and nitroquinoline intercalators [104], minor groove binders [105], and polyamine conjugates [106]. Even pimonidazole was shown to be ‘concentrated’ near DNA relative to misonidazole [107,108].
Sequence-specific recognition and modification of double-helical DNA by minor-groove binding conjugates structurally related to netropsin and distamycin
1998, Advances in DNA Sequence-Specific AgentsSynthesis, in vitro aerobic and hypoxic cytotoxicity and radiosensitizing activity of novel metronidazole tethered 5-fluorouracil
2013, DARU, Journal of Pharmaceutical SciencesSequence-specific DNA minor groove binders. Design and synthesis of netropsin and distamycin analogues
1998, Bioconjugate Chemistry
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