Recent developments in DNA topoisomerase II structure and mechanism
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2023, International Journal of Biological MacromoleculesCitation Excerpt :Results revealed that topoisomerase IIα (3′-hydroxydaunorubicin and the ohlivacine derivative) eliminates Ras-positive oncogenes but not the wild [73]. In another related investigation, another group of scientists found that merbarone causes apoptosis activating caspase3-like protease in drug-sensitive CEM cell lines and ICRF-187 in CEM drug resistance without activating JNK1 [43,44]. Another multi-targeting investigation done by Ma et al. 2016 suggests that a bis-fluoroquinolone chalcone-like derivative (HMNE3) inhibits the activity of both tyrosine kinases and topoisomerase II and causes apoptosis in cancer cells [43].
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