TREND TOWARD A REDUCED PREVALENCE OF HELICOBACTER PYLORI INFECTION, CHRONIC GASTRITIS, AND GASTRIC CANCER IN JAPAN
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CHANGING PATTERNS OF GASTRIC CANCER IN JAPAN
Although the mortality rate of gastric cancer in Japan has declined (Fig. 1),1 there is no obvious explanation for the decline. One possible explanation is the increase in detection of early gastric cancer. A previous study21 on clinicopathologic features of 861 patients with gastric cancer resected in 1975, 1985, and 1995 indicated that the prevalence of early gastric cancer increased from 27.4% in 1975, to 40.2% in 1985, to 65.6% in 1995 (Fig. 2). This increase is attributed to the spread of
TIME TRENDS IN HELICOBACTER PYLORI INFECTION AND IN GASTRITIS IN JAPAN
The prevalence of H. pylori infection is significantly higher in developing than in developed countries (Fig. 3)12, 13, 27 and is closely related to low socioeconomic status.12, 14 Japan is an exception among the developed countries in that the prevalence of H. pylori infection in people older than 50 years old is approximately 80%, which is similar to that in developing countries. Because Japan's position among developed nations emerged in the past few decades, it is important to investigate
SUMMARY
It is speculated that declines in H. pylori infection and gastritis over the past few decades may lead to a decline in gastric cancer in Japan, supplemented by excellent procedures for the early detection of gastric cancer. Because H. pylori infection rarely is acquired in adult life, once it is eradicated, reinfection would not be expected in adult patients. It seems likely that adequate treatment of H. pylori infection would provide long-term protection against gastric cancer.
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Cited by (26)
Occurrence of Helicobacter pylori in saliva from preschool-age children
2015, Oral Science InternationalCitation Excerpt :H. pylori infection is reported to have a high incidence rate in developing countries and a low rate in developed countries [32]. In Japan, there is a biphasic pattern: the infection rate among people aged ≤20 years is approximately 20%, or roughly the same as in major developed countries, but among people aged ≥50 years, it is high at 60% or higher [22]. The infection rate is high in developing countries that do not have adequate water and sewer services or have a poor sanitation environment [19,32], and reports from China [33] and Russia [34], where there has been remarkable economic growth and the sanitation environment is being improved, show a biphasic pattern of infection similar to Japan.
Prevalence and risk-factors for Helicobacter pylori infection in urban and rural Beninese populations
2005, Clinical Microbiology and InfectionCitation Excerpt :Helicobacter pylori infection is associated with a range of gastric and duodenal lesions [1–3], and is a class I carcinogenic agent, involved in gastric carcinogenesis as well as in development of gastric lymphomas of the MALT type [1–3].
Different Pathophysiology of Gastritis in East and West? A Western Perspective
2016, Inflammatory Intestinal DiseasesPrevalence and risk factors of Helicobacter pylori infection in asymptomatic Chinese children: A prospective, cross-sectional, population-based study
2015, Alimentary Pharmacology and Therapeutics
Address reprint requests to Ken Haruma, MD, Gastrointestinal Unit, First Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734, Japan, e-mail: [email protected]