Research papercAMP increases K+ secretion via activation of apical IsK/KvLQT1 channels in strial marginal cells
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2016, Progress in Molecular Biology and Translational ScienceCitation Excerpt :While the mutations in KCNQ1 are responsible for LQTS type 1 (LQT1), mutations in KCNE1 are responsible for LQTS type 5 (LQT5).175,176 In addition to the heart, KCNQ1 and KCNE1 are expressed in other organs including the ear, gastrointestinal tract, and kidney.177–180 It was shown that targeted disruption of the KCNQ1 gene causes deafness and gastric hyperplasia in mice.181
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