Journal of Chromatography B: Biomedical Sciences and Applications
Regular paperStereoselective and simultaneous measurement of cis- and trans-isomers of doxepin and N-desmethyldoxepin in plasma or urine by high-performance liquid chromatography
References (12)
- et al.
J. Pharm. Sci.
(1978) - et al.
Arzneim.-Forsch.
(1981) - et al.
Drug Metab. Dispos.
(1990) - et al.
Ther. Drug Monit.
(1990) - et al.
Eur. J. Clin. Pharmacol.
(1992)
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Highly sensitive LC–MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study
2018, Journal of Pharmaceutical AnalysisCitation Excerpt :Other methods report simultaneous estimation of Dox and NDox in a variety of biological samples like whole blood [5], gastric fluids [5], bile, urine [5], cerebrospinal fluid [5], tissues [5], hair [7], urine [11] and human plasma [11–13]. A majority of these methods were developed for forensic or toxicological studies but only few of them addressed the pharmacokinetics of Dox and NDox in human plasma [11,13]. Moreover, they have limited sensitivity (lower limit of quantitation) in the range of 0.25–100 ng/mL for both the analytes.
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2014, Recent Advances in Medicinal ChemistryExtractive spectrophotometric methods for the determination of doxepin hydrochloride in pharmaceutical preparations using titanium (IV) and iron (III) thiocyanate complexes
2005, FarmacoCitation Excerpt :Gas liquid chromatography, high performance liquid chromatography, thin-layer chromatography, and capillary electrophoresis [13–26] have been applied to determination of doxepin in biological fluids. Gas chromatography and high performance liquid chromatography have been also used for separation or quantify low concentrations of doxepin geometric isomers [27–29]. Some studies have proposed potentiometric sensors [30] to be used in determination of doxepin cation in a substance and in its pharmaceutical preparations.
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