Nicergoline facilitates vestibular compensation in aged male rats with unilateral labyrinthectomy

doi:10.1016/S0304-3940(99)00328-6

Neuroscience Letters

Volume 267, Issue 2, 28 May 1999, Pages 93-96

https://doi.org/10.1016/S0304-3940(99)00328-6 Get rights and content

Abstract

The ergoline derivatives, nicergoline (NIC) or dihydroergocristine (DHE) were administered at various doses (0.1, 0.5 and 1 mg/kg) to aged male rats subjected to labyrinth unilateral lesion (LBX). The nystagmus rate appeared to be lower in animals treated with DHE or NIC 1mg/kg than in saline-injected rats, when observed on day 1 and 2 after operation. The number of falls in the rotorod test of LBX animals was decreased by NIC 0.5 or 1 mg/kg at all observation times. This parameter was affected by DHE only at the higher dose. These results suggest that NIC facilitates vestibular compensation of LBX rats. DHE appeared to be less potent in this respect. Since both drugs act on central dopaminergic neurotransmission, it is possible that this neurotransmission may be involved in their mechanism of action.

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Unfortunately, the most commonly used tests for vestibular dysfunction in mouse clinical models are not specific. For example, the rotorod test is currently used to assess vestibular and motor function (e.g., Drago et al., 1996; Rampello and Drago, 1999; Deiss et al., 2000; Fasipe et al., 2004; Jones et al., 2004). It uses an apparatus that consists of a thin horizontally oriented spinning rod with disks that define test compartments.
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Nicergoline facilitates vestibular compensation in aged male rats with unilateral labyrinthectomy

Abstract

Neurosci. Lett.

Pharm. Res. Commun.

Pharmacol. Res.

Brain Res.

Brain Res.

Role of the spinal cord in compensating the effects of hemilabyrinthectomy

Arch. Ital. Biol.

Drug interference on some biochemical parameters of rat cerebral cortex during post-ischaemic recovery

Arch. Intern. Pharmacodyn. Ther.

Effects of dihydroergocristine on experimental models of vertigo

Acta Therapeut.