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2021, Materials Science and Engineering CCitation Excerpt :For human collagen, the biophysical and biochemical properties are related closely with ethnicity, age and genotypes of the donor, resulting in inter-batch quality instability of extracted collagen [16]. It has been found that intermolecular cross-linking of collagen increased in the aged donor, and is considered to be responsible for the increased resistance to collagenase, decreased elasticity and degradation of aged collagen in vivo [17–19]. The advance of recombinant technique enabled the availability of a chemically defined and reliable sources of proteins.
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2020, Radiation Physics and ChemistryCitation Excerpt :Regarding to the evaluation of immune behaviour of collagen, a series of studies revealed that a pre-existing sensitivity to bovine collagen ranged between 2 and 4%, and development of a postoperative allergy was found just to 1% of investigated patients. Incidence of adverse reactions, as granuloma and localized inflammation have been observed in rare cases, bellow 3% (Cooperman and Michaeli, 1984; Lynn et al., 2004). Other studies showed that after injections of bovine collagen, no apparent sensitivity or rare incidence of granuloma (bellow 0.01%) were reported by Stolman (2005) and Lemperle (Lemperle et al., 2003).
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