Original articleOverrepresentation of 1q21–23 and 12q13–21 in lipoma-like liposarcomas but not in benign lipomas: A comparative genomic hybridization study
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Molecular cytogenetic anomalies and phenotype alterations in a newly established cell line from Wilms tumor with diffuse anaplasia
2008, Cancer Genetics and CytogeneticsCitation Excerpt :Candidate genes located at 1q21∼q22 that could be involved in Wilms tumor pathogenesis include the CKS1B, PSMD4, MUC1, TGFB2, IL6R, MCL1, TPM3 (alias TRK), and SKI genes. The regulatory sequences of an unknown putative target gene for Wilms tumor were recently mapped to 1q21∼q22 [26]; however, gain of 1q21∼q22 sequences has also been observed in leiomyosarcomas [27], lipoma-like liposarcomas [28], osteosarcomas [29], and multiple myeloma [30]. The second region with significant copy number gain detected by CGH in WT-Pe.1 cells covers the entire 4 p arm.
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2007, Mayo Clinic ProceedingsCitation Excerpt :A prognostic nomogram specific for liposarcomas has recently been described that may facilitate stratification for clinical trials and aid in the counseling of patients.145 Although the etiology of liposarcoma is unknown, a variety of cytogenetic abnormalities have been described, and gain of 1q and 12q sequences is commonly observed.146,147 The PPAR and CEBP families of transcription factors play important roles in adipocyte differentiation.148,149
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