Preliminary CommunicationsEXPERIMENTAL TRANSMISSION OF LEGIONNAIRES' DISEASE BY EXPOSURE TO AEROSOLS OF LEGIONELLA PNEUMOPHILA
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Cited by (99)
Modelling Legionnaires’ disease: Lessons learned from invertebrate and vertebrate animal models
2023, European Journal of Cell BiologyEpidemiological analysis of Legionnaires' disease in Scotland: a genomic study
2022, The Lancet MicrobeCitation Excerpt :More than 30 Legionella species can invade immune cells and cause opportunistic human respiratory infections.1 However, over 90% of infections are caused by a single species, Legionella pneumophila, which is typically inhaled from contaminated environmental aerosols.2 Legionellosis varies from a mild flu (Pontiac fever) to Legionnaires' disease, an atypical, often severe form of pneumonia with a 10% mortality rate.1
The mysterious illness that drove them to their knees - Ah, that Legionnaires’ disease – A historical reflection of the work in Legionnaires’ disease in New Zealand (1978 to mid-1990s) and the ‘One Health’ paradigm
2020, One HealthCitation Excerpt :The epidemiological investigation led by David Fraser of the US CDC into the 1976 LD outbreak suggested the disease was most probably spread by the air borne route [49] but the ubiquitous presence of Legionella spp. in the environment was not fully known until 1980. By 1981 evidence for confirmation of human exposure to LD via an airborne route was obtained [50] through inducing experimental respiratory infection in guinea pigs and rhesus monkeys using a strain of L. pneumophila that was isolated from a contaminated domestic water supply. In 1979 the NHI provided the back-up for New Zealand’s first occurrence of L. pneumophila infection via serological immunocytological and histological techniques and was reported in the New Zealand Medical Journal [51].
Risk of infection from Legionella associated with spray irrigation of reclaimed water
2018, Water ResearchCitation Excerpt :When guinea pigs are exposed to aerosols of L. pneumophila they develop a pneumonic illness characterized by fever, weight loss and labored respirations that sometimes results in death. This syndrome resembles Legionnaires disease in humans (Berendt et al., 1980; Baskerville et al., 1981; Breiman and Horwitz, 1987). Berendt et al. (1980) carried out experiments to determine the infectivity and lethality of exposure to L. pneumophila, using guinea pigs.
From Single Cells to Engineered and Explanted Tissues: New Perspectives in Bacterial Infection Biology
2015, International Review of Cell and Molecular BiologyCitation Excerpt :Tissue explants play an important role in in vitro analysis of bacterial pathogens showing restrictive species-specificities such as the human pathogen of Legionnaires' disease L. pneumophila for the human lung. Until recently, mammalian models such as guinea pigs, mice, rhesus monkeys, and marmosets were employed to address immunological, pathological, and pharmacological questions (Baskerville et al., 1981; Blanchard et al., 1987; Fitzgeorge et al., 1983), although data from these animal models cannot be easily generalized because of important interspecies differences in the expression, function, and localization of immune molecules (e.g., receptors, signaling intermediates, response molecules). Cell culture assays on the other hand lack the complex interaction networks between the specialized cell types and extracellular components in the human lung.