Hypothesis: HOMING OF LYMPHOCYTES TO NON-LYMPHOID TISSUES
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Cited by (41)
Pure abscopal effect of radiotherapy in a salivary gland carcinoma: Case report, literature review, and a search for new approaches
2020, Cancer/RadiotherapieCitation Excerpt :They hypothesized that skin—and, by extension, the rest of the body—was a mosaic of clonal cell populations that harbored different susceptibilities to autoimmune insults, which would account for the appearance of isolated (and at times symmetrically distributed) lesions on the skin surface, affecting one specific portion of the skin surface rather than all of it [238]. They intuited that a similar process might explain how and why B and T lymphocytes homed to distinct anatomical compartments [239] and that, if transformed, they might home to some particular body site or set of body sites that expressed some particular epitope corresponding to the receptor expressed by the neoplastic lymphocyte [239,240]. If their intuition was correct, and if the specific epitope could be identified, then it might be possible to block the receptor of the neoplastic lymphocyte or the epitope of the target site and treat the corresponding disease [240].
Diffuse large B-cell lymphoma of the orbit: Clinicopathologic, immunohistochemical, and prognostic features of 20 cases
2012, American Journal of OphthalmologyCitation Excerpt :For example, B-cell biomarkers vary from tumor to tumor. Selective or exclusive involvements of different extranodal sites (testes, bowel, among others) can be seen, implying a set of cell surface receptors that can interact with tissue-specific antigens.27 DLBCL can arise de novo or be associated with states of immunodeficiency precipitated by disease or medications (methotrexate, fludarabine).3,28,29
Ocular Adnexal Lymphoid Tumors: Progress in Need of Clarification
2008, American Journal of OphthalmologyCitation Excerpt :There are two fundamental ways of looking at OALs: from the perspective of putatively predictive features that may be distinctive to the local lesions, or from the perspective of how OALs relate to better characterized systemic nodal and extranodal tumors. The ultimate goal is to find any parameter7—architectural, histopathologic, cytologic, precise anatomic localization, T-cell and B-cell composition, expanded immunophenotypic profiling, gene rearrangements, chromosomal translocations, transcription factors, nonimmunoglobulin cell-surface receptors, so-called homing or ecotaxic receptors,8 detectable traces of infectious agents9—that establish the origin, course, prognosis, and long-term clinical outcome. In other words, which OALs are primary, that is, arising in the ocular adnexa, and are likely to remain localized after appropriate therapy (usually radiotherapy), and which herald or are concurrently discovered to be part of a systemic disease?
Hypothesis: symmetrical cutaneous lymphoma
1990, The Lancet8 Immunology of gastrointestinal lymphoma
1987, Bailliere's Clinical GastroenterologyOcular Adnexal Monoclonal Lymphoid Tumors with a Favorable Prognosis
1986, Ophthalmology