Preliminary CommunicationsASSOCIATION OF AUTOIMMUNE ACTIVE CHRONIC HEPATITIS WITH HL-A1,8
References (25)
- et al.
Lancet
(1964) - et al.
Lancet
(1970) - et al.
Lancet
(1966) - et al.
Lancet
(1972) - et al.
Adv. Immun.
(1968) - et al.
Science
(1972) Eur.J. Immun.
(1971)- et al.
J. natn. Cancer Inst.
(1968) J. natn. Cancer Inst.
(1970)Histocompatibility Testing
(1967)
New Engl. J. Med.
Tissue Antigens
Cited by (257)
De novo autoimmune hepatitis –is this different in adults compared to children?
2018, Journal of AutoimmunityCitation Excerpt :After the detection of smooth muscle antibody, the term ‘autoimmune’ chronic active hepatitis was used to distinguish this condition from lupus erythematosus [4]. In the early 1970's the response to immunosuppression [5] and link to HLA antigens B8 DR3 [6], made the ‘autoimmune’ basis of this condition more widely accepted [7]. Following the discovery of the hepatitis C virus in 1989, an international panel of experts (international autoimmune hepatitis group - IAIHG) met in Brighton, United Kingdom to make recommendations regarding the diagnosis of AIH.
Genetics of liver disease: From pathophysiology to clinical practice
2015, Journal of HepatologyAutoimmune Hepatitis
2012, Zakim and Boyer's HepatologyGastrointestinal: Liver
2011, Systemic Lupus ErythematosusDoes HLA-DR7 differentiate the overlap syndrome of auto-immune hepatitis-primary biliary cirrhosis (AIH-PBC) from those with auto-immune hepatitis type 1?
2011, Annals of HepatologyCitation Excerpt :There was no influence in any allele class DR in OS but HLA-DR7 was able to distinguish between AIH and OS. Previous studies have shown that the genetic expression leads to different a presentation of the disease in AIH; that is the case of DRB1*0301 in younger patients, showing severe disease comparing to those with DRB1*0401.9-12 There are different genes that modify the phenotypic expression of AIH, which include the presence of TNFA*2 polymorphisms, associated with poor response to treatment with steroids13,14 and the presence of CTLA-4 which is related with extra-hepatic manifestations and TNFRSF6 with progression to cirrhosis.15
Autoimmune hepatitis
2010, Best Practice and Research: Clinical GastroenterologyCitation Excerpt :This includes shaping of the T-cell repertoire, peptide selection and presentation as well as peptide transport. Mackay and Morris already reported HLA A1 and B8 association and AIH in 1972 [38]. Genetic variability is not limited to the HLA I and II genes but equally affects TNFα and β, complement genes, MICA, and MICB.