ORIGINAL ARTICLESTREATMENT OF ALCOHOLISM WITH A SENSITISING DRUG
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2019, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :Disulfiram (tetraethylthiuram disulfide, DSF) acts as a copper ionophore and increases intracellular bioavailable copper levels. It is a consolidate drug for the treatment of alcoholism, since it inhibits acetaldehyde dehydrogenase [84], and the first evidence on its efficacy in cancer treatment dates back to 1977 when it was used for an alcoholic patient affected by metastatic breast cancer [89]. DSF showed copper-dependent anticancer properties in vitro and in vivo and inhibits proliferation, migration and invasion of HCC (hepatocellular carcinoma cells) by impairing both NF-κB and TGFβ signaling [90].
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