ORIGINAL ARTICLESLIPODYSTROPHY AND HEPATOMEGALY WITH DIABETES, LIPÆMIA, AND OTHER METABOLIC DISTURBANCES: A CASE THROWING NEW LIGHT ON THE ACTION OF INSULIN☆
References (0)
Cited by (135)
Genetics of lipodystrophy syndromes
2021, Presse MedicaleCitation Excerpt :Cautions should be taken when analyzing variants in a given gene, when there is no robust evidence to support the gene-disease association. For example, in the case of LS, evidence to support the implication of ADRA2A is currently limited [3] and clear association between the alpha-2-adrenergic receptor and disease has not been yet established. Another example is that of the PLIN1 gene encoding perilipin-1, a key protein for lipid droplet formation and triglyceride metabolism.
Lipodystrophy
2018, Encyclopedia of Endocrine DiseasesLate-onset acquired generalized lipodystrophy with muscle involvement
2012, Actas Dermo-SifiliograficasThematic review series: Lipid droplet synthesis and metabolism: From yeast to man - Seipin: From human disease to molecular mechanism
2012, Journal of Lipid ResearchCitation Excerpt :However, with more extreme fat loss, the patient's metabolic condition becomes more severe. The first thorough characterization of the effects of whole-body, or generalized, lipodystrophy was published by R. D. Lawrence in 1946 (3). This syndrome was often termed “lipoatrophic diabetes” because of the striking metabolic picture that accompanies fat loss.
Monogenic severe insulin resistance syndromes
2005, Revue de Medecine InternePPARγ: A critical determinant of body fat distribution in humans and mice
2005, Trends in Cardiovascular Medicine
- ☆
The Oliver-Sharpey lectures delivered at the Royal College of Physicians of London on March 19 and 20, 1946.