Elsevier

The Lancet

Volume 361, Issue 9351, 4 January 2003, Pages 45-46
The Lancet

Research Letters
Autologous bone-marrow stem-cell transplantation for myocardial regeneration

https://doi.org/10.1016/S0140-6736(03)12110-1Get rights and content

Summary

Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5×106 autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a myocardial infarction and undergone coronary artery bypass grafting. 3–9 months after surgery, all patients were alive and well, global left-ventricular function was enhanced in four patients, and infarct tissue perfusion had improved strikingly in five patients. We believe that implantation of AC133+ stem cells to the heart is safe and might induce angiogenesis, thus improving perfusion of the infarcted myocardium.

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