Parameter estimation of an enzyme kinetic system using computer algebra techniques

doi:10.1016/S0096-3003(97)10178-3

Applied Mathematics and Computation

Volume 99, Issue 1, 1 March 1999, Pages 93-98

https://doi.org/10.1016/S0096-3003(97)10178-3 Get rights and content

Abstract

A procedure for fitting enzyme kinetic data directly to the flux equation was described. It involves choosing parameters that minimize the sum of the squares of deviations due to errors in s, the substrate concentration at time t. Estimates of the standard errors of the parameters are provided using computer algebra and numerical analysis techniques.

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Parameter estimation of an enzyme kinetic system using computer algebra techniques

Abstract

Comput. Biomed. Res.

J. Biol. Chem.

J. Biol. Chem.

Comput. Biomed. Res.

Biochimica Biophysia Acta

Biochimica Biophysia Acta

Trends Biochem. Sci.

FEBS Lett.

Error structure of enzyme kinetic experiments

European J. Biochem.

The reliability of Michaelis constants and maximum velocities estimated by using the integrated Michaelis-Menten equation

Biochem. J.

A simple digital computer program for estimating the parameters of the Hill equation

European J. Biochem.

Using computer algebra to determine rate constants in biochemistry

A simple general purpose technique for interfacing between computer algebra and numerical analysis systems, Design and Implementation of Symbolic Computation Systems (DISCO-92)

Numerical treatment of inverse problems in chemical reaction kinetics

Analytical methods for fitting integrated rate equations

Biochem. J.