Clinical Immunology and Immunopathology
Autoantibodies to the collagen-like region of C1Q deposit in glomeruli via C1Q in immune deposits1
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Cited by (42)
Abnormalities in immune complex clearance and apoptotic cell clearance
2018, Dubois' Lupus Erythematosus and Related SyndromesAnti-C1q autoantibodies from systemic lupus erythematosus patients activate the complement system via both the classical and lectin pathways
2015, Clinical ImmunologyCitation Excerpt :With regard to downstream mechanisms, anti-C1q are believed to involve both, activation of the complement system as well as recruitment of Fc receptors upon binding to e.g., C1q-containing ICs deposited in the kidneys with consecutive amplification of the inflammatory process during flares [12]. Anti-C1q were described to bind to C1q-containing ICs deposited in mouse glomeruli [44] leading to the hypothesis that C1q bound to ICs deposited in the kidneys serves as a target for anti-C1q. Next to its involvement in host defense, the complement system has multiple other functions such as bridging innate with adaptive immunity and clearing apoptotic cell material.
Immune Complexes in Systemic Lupus Erythematosus
2011, Systemic Lupus ErythematosusImmune Complexes in Systemic Lupus Erythematosus
2010, Systemic Lupus Erythematosus, Fifth EditionPathogenicity of anti-DNA/glomerular autoantibodies - Weighing the evidence
2004, Drug Discovery Today: Disease ModelsImmune complexes
2004, Systemic Lupus Erythematosus, Fourth Edition
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Presented in part at the 23rd Annual Meeting of the American Society of Nephrology, Washington, D.C., December 1990.
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Present address: Division of Immunology, Clinical Research Institute, National Medical Center, 1-21-1 Toyama, Shinjuku-ku, Tokyo, Japan.