Leptin and melanocortin signaling in the hypothalamus
References (188)
- et al.
Activation of downstream signals by the long form of the leptin receptor
J. Biol. Chem.
(2000) - et al.
SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats
Regul. Pept.
(2000) - et al.
Neuropeptide Y release in the paraventricular nucleus of Long-Evans rats treated with leptin
Biochem. Biophys. Res. Commun.
(1998) - et al.
A role for leptin and its cognate receptor in hematopoiesis
Curr. Biol.
(1996) - et al.
Divergent signaling capacities of the long and short isoforms of the leptin receptor
J. Biol. Chem.
(1997) - et al.
Identification of SOCS-3 as a potential mediator of central leptin resistance
Mol. Cell
(1998) - et al.
The role of SOCS-3 in leptin signaling and leptin resistance
J. Biol. Chem.
(1999) - et al.
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
J. Biol. Chem.
(2000) - et al.
Divergent roles of SHP-2 in ERK activation by leptin receptors
J. Biol. Chem.
(2001) - et al.
Molecular characterization of the mouse agouti locus
Cell
(1992)
Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
Cell
Exocrine gland dysfunction in MC5-R-deficient mice: Evidence for coordinated regulation of exocrine gland function by melanocortin peptides
Cell
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
Dev. Cell
Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA
FEBS Lett.
Central leptin regulates the UCPI and ob genes in brown and white adipose tissue via different beta-adrenoceptor subtypes
J. Biol. Chem.
Mutation screening and identification of a sequence variation in the human ob gene coding region
Biochem. Biophys. Res. Commun.
Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat
Neuron
Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding
J. Biol. Chem.
Agouti and agouti-related protein: Analogies and contrasts
J. Biol. Chem.
Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area
Neuron
Leptin activates hypothalamic CART neurons projecting to the spinal cord
Neuron
From lesions to leptin: Hypothalamic control of food intake and body weight
Neuron
Identification of the Y985 and y]1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
FEBS Lett
ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors
Biochem. Biophys. Res. Commun.
Molecular cloning of a novel melanocortin receptor
J. Biota Chem.
Molecular cloning, expression, and gene localization of a fourth melanocortin receptor
J. Biol. Chem.
Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor
J. Biol. Chem.
Differential expression of mRNA for leptin receptor isoforms in the rat brain
Mol. Cell. Endocrinol.
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
Cell
Leptin rapidly inhibits hypothalamic neuropeptide Y secretion and stimulates corticotropin-releasing hormone secretion in adrenalectomized mice
J. Nutr
Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor
Peptides
Regulation of neuropeptide Y release from hypothalamic slices by melanocortin-4 agonists and leptin
Peptides
Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor
J. Biol. Chem.
Role of leptin in the neuroendocrine response to fasting
Nature
Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics
J. Med. Chem.
Pituitary corticotroph SOCS-3: Novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion
Mol. Endocrinol.
Anatomy of an endogenous antagonist: Relationship between Agouti-related protein and proopiomelanocortin in brain
J. Neurosci.
Leptin receptor-STAT3 signaling integrates energy balance and metabolic homeostasis
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors
PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues
Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a P13-kinase mediated effect
Diabetologia
Expression of leptin receptor isoforms in rat brain microvessels
Endocrinology
Regulation of POMC expression by leptin: Roles of STAT3 and cAMP
Inhibition of hypothalamic thyrotropin-releasing hormone messenger ribonucleic acid during food deprivation
Endocrinology
Independent and additive effects of central POMC and leptin pathways on murine obesity
Science
Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing
J. Clin. Invest.
The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
Endocrinology
Melanocortin4 receptor is required for acute homeostatic responses to increased dietary fat
Nat. Neurosci.
Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
Science
Cited by (26)
Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control
2019, Molecular MetabolismCitation Excerpt :There is increasing evidence that highlights a potential melanocortin-dependent compensatory/additive role for GLP-1Rs in the absence/presence of leptin. In particular, the acute effects of GLP-1 receptor activation in melanocortin neurons mirrors that of the description of leptin [33–37]. GLP-1 may also be beneficial in the absence of leptin [38,39].
NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways
2011, Cell MetabolismCitation Excerpt :Two possible mechanisms have been proposed to explain leptin's actions on the HPT axis. These two mechanisms both involve hypothalamic neurocircuitry that regulates TRH production in the PVN: (1) Leptin acts directly through its receptors on hypophysiotropic TRH neurons that project to the median eminence to regulate TSH production in the pituitary (Harris et al., 2001; Nillni et al., 2000; Perello et al., 2006); or (2) leptin regulates TRH neurons indirectly via its actions on pro-opiomelanocortin (POMC) and agouti-related peptide/neuropeptide Y (AgRP/NPY) neurons in the arcuate nucleus (Bjørbaek and Hollenberg, 2002; Fekete et al., 2001; Fekete et al., 2000a; Fekete et al., 2002b; Legradi et al., 1998). Although these pathways are not mutually exclusive, genetic data suggest that leptin signaling is absolutely required for normal function of the HPT axis as mice with leptin receptor mutations have central hypothyroidism whereas mice that lack the MC4R or NPY have normal T4 levels at baseline (Bates et al., 2004; Erickson et al., 1997; Fekete et al., 2004).
Role of Thyrotropin-Releasing Hormone in the Regulation of the Thyroid Axis
2009, Clinical Management of Thyroid DiseaseThe role of syndecans in disease and wound healing
2006, Matrix BiologyIdentification of the Downstream Targets of SIM1 and ARNT2, a Pair of Transcription Factors Essential for Neuroendocrine Cell Differentiation
2003, Journal of Biological ChemistryCitation Excerpt :Jak2 is thought to be a positive participant in leptin receptor signaling (34, 35). Both melanocortin-stimulating hormone and leptin are well known negative regulators of food intake (36). Although their actions have been investigated in the arcuate nucleus, their actions in the PVN are less well studied.