Correlation of Anatomical and Biochemical Development of the Rabbit Neostriatum

https://doi.org/10.1016/S0079-6123(08)60688-3Get rights and content

Publisher Summary

This chapter focuses on the correlation of anatomical and biochemical development of the rabbit neostriatum. The chapter presents data on (1) the endogenous levels of dopamine in the neostriatum at each stage and the ability of the tissue to take up exogenous dopamine, (2) the time of appearance and pattern of distribution of dopamine fluorescence, (3) the correlation of electron microscopic profiles of developing and mature synapses with changing fluorescent patterns, and (4) the formation of dense material within axonal vesicles of tissue slices of neostriatum after incubation in 5- or 6-hydroxydopamine. Dopamine has been recognized in recent years as one of the neuromodulators in the nervous system. It captured the attention of many investigators because of its role in the extrapyramidal motor system. The origin of dopamine in the neostriatum was uncertain until fluorescence microscopy studies demonstrated dopamine-containing neurons in the substantia nigra, which send axons to the caudate nucleus and putamen to form the nigroneostriatal tract.

References (49)

  • I. Sano et al.

    Biochim. Biophys. Acta

    (1959)
  • N.E. Andén et al.

    Life Sci.

    (1964)
  • A.M. Adinolfi

    Brain Res.

    (1971)
  • J. Kemp

    Brain Res.

    (1968)
  • H.C. Agrawal et al.

    Int. J. Neuropharmacol.

    (1968)
  • L.A. Loizou

    Brain Res.

    (1972)
  • L.A. Loizou et al.

    Brain Res.

    (1970)
  • J.D. Connor et al.

    Life Sci.

    (1970)
  • V.M. Tennyson et al.

    Brain Res.

    (1972)
  • G.S. Golden

    Brain Res.

    (1972)
  • J. Kemp

    Brain Res.

    (1968)
  • T. Hökfelt

    Brain Res.

    (1970)
  • A. Bertler et al.

    Experientia

    (1959)
  • A. Carlsson

    Pharmacol. Rev.

    (1959)
  • A Carlsson et al.

    Acta Physiol. Scand.

    (1962)
  • K. Fuxe et al.

    Z. Zellforsch.

    (1964)
  • K. Fuxe et al.

    Am. J. Anat.

    (1965)
  • A. Dahlström et al.

    Acta Physiol. Scand.

    (1964)
  • A.M. Adinolfi et al.

    J. Comp. Neurol.

    (1968)
  • G.K. Aghajanian et al.

    J. Pharmacol. Exp. Ther.

    (1967)
  • I.J. Bak

    Exp. Brain Res.

    (1967)
  • C.A. Fox et al.

    J. Hirnforsch.

    (1971-72)
  • J. Kemp et al.

    Phil. Trans. R. Soc. London, Ser. B

    (1971)
  • J. Kemp et al.

    Phil. Trans. R. Soc. London, Ser. B

    (1971)
  • Cited by (10)

    View all citing articles on Scopus
    View full text