Elsevier

Transplantation Proceedings

Volume 31, Issue 6, September 1999, Pages 2250-2251
Transplantation Proceedings

Fifth Congress of the Catalan Society
Acute tacrolimus nephrotoxicity in renal transplant patients treated with clarithromycin

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Case reports

We present two patients who developed acute nephrotoxicity after administration of a macrolide antibiotic, clarithromycin (CLR). The patients were two females aged 37 (P-1) and 69 (P-2) years old who underwent kidney transplantation 17 (P-1) and 5 months (P-2) earlier. Patient 1 was inmunosuppressed with TCR (4 mg daily), mycophenolate mofetil, and prednisone; patient 2 was inmunosuppressed with TCR (4 mg daily), azathioprine, and prednisone. The graft function was good, with baseline

Discussion

Drug interaction between TCR and CLR in renal transplantation has been previously described in two separate cases.4, 5 This interaction results in an increase of TCR blood levels in may be nephrotoxic in the same way that cyclosporine is. Acute tacrolimus nephrotoxicity is reversible, and it responds well to reduction in the drug dosage.5 In our experience, azithromycin, another macrolide antibiotic, is an alternative drug to CLR because this antibiotic does not interact significantly with TCR,

References (5)

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    Curr Opin Nephrol Hypertens

    (1998)
There are more references available in the full text version of this article.

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