Elsevier

Transplantation Proceedings

Volume 32, Issue 7, November 2000, Pages 1793-1794
Transplantation Proceedings

Kidney–rejection and monitoring
Better clinical outcome in renal transplant recipients with peripheral blood microchimerism

https://doi.org/10.1016/S0041-1345(00)01370-1Get rights and content

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Patients and methods

Twenty-two patients who underwent renal transplantation at Sakura National Hospital between October 1980 and August 1992 were studied. Eleven kidneys were from living-related donors and the other 11 were from cadaver donors. All recipients showed good and stable renal function (graft survival time, 4.0 to 16 years, average 10.8 years) at the time of the study of their chimeric state between 1995 and 1996. As maintenance immunosuppression, 15 cases were receiving cyclosporine and prednisolone;

Frequency of PBMC after renal transplantation

PBMC were detected in 8 of 22 renal transplant recipients. Thirteen female patients who underwent renal transplantation from male donors were checked by DYZ1, and microchimeric bands were detected in 6 of 13 cases in peripheral blood cells. Eleven patients who received HLA-DRB1 mismatched kidney allografts were checked by DRB1-specific primers, and macrochimeric bands were detected in 3 of 11 cases in peripheral blood cells. Two patients were checked by both methods, and PBMC was detected in

Discussion

There have been controversial discussions concerning the relation between microchimerism and donor-specific tolerance in renal transplantation.1, 2 However, recent studies raised doubts about a role of chimerism to establish donor-specific tolerance because of infrequency of PBMC in long-term survivors5 or undergoing rejection despite donor-specific chimerism.6

As previously reported, we have found some correlation between the microchimerism and better HLA-DRB1 matched status in renal transplant

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There are more references available in the full text version of this article.

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