Kidney–rejection and monitoringBetter clinical outcome in renal transplant recipients with peripheral blood microchimerism
Section snippets
Patients and methods
Twenty-two patients who underwent renal transplantation at Sakura National Hospital between October 1980 and August 1992 were studied. Eleven kidneys were from living-related donors and the other 11 were from cadaver donors. All recipients showed good and stable renal function (graft survival time, 4.0 to 16 years, average 10.8 years) at the time of the study of their chimeric state between 1995 and 1996. As maintenance immunosuppression, 15 cases were receiving cyclosporine and prednisolone;
Frequency of PBMC after renal transplantation
PBMC were detected in 8 of 22 renal transplant recipients. Thirteen female patients who underwent renal transplantation from male donors were checked by DYZ1, and microchimeric bands were detected in 6 of 13 cases in peripheral blood cells. Eleven patients who received HLA-DRB1 mismatched kidney allografts were checked by DRB1-specific primers, and macrochimeric bands were detected in 3 of 11 cases in peripheral blood cells. Two patients were checked by both methods, and PBMC was detected in
Discussion
There have been controversial discussions concerning the relation between microchimerism and donor-specific tolerance in renal transplantation.1, 2 However, recent studies raised doubts about a role of chimerism to establish donor-specific tolerance because of infrequency of PBMC in long-term survivors5 or undergoing rejection despite donor-specific chimerism.6
As previously reported, we have found some correlation between the microchimerism and better HLA-DRB1 matched status in renal transplant
References (6)
- et al.
Lancet
(1994) - et al.
Transplant Proc
(1997) - et al.
Transplant Proc
(1998)
Cited by (5)
Microchimerism in Peripheral Blood and Urine in Renal Transplant Recipients: Preliminary Results
2008, Transplantation ProceedingsCitation Excerpt :These results are consistent with our results on peripheral blood as our population had undergone cadaveric renal transplantations (16/17). In contrast, Sakamoto et al observed microchimerism in the peripheral blood of 6/13 female renal recipients with gender-mismatched donors, reporting a slightly better outcome among patients with chimerism compared with others where chimerism could not be detected.12 In a meta-analysis of 37 articles on microchimerism Sahota et al reported that blood microchimerism was associated with a greater incidence of acute kidney transplant rejection, especially at 12 months and beyond and that microchimerism was organ- and time-dependent.13
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