Elsevier

Toxicon

Volume 39, Issue 5, May 2001, Pages 725-727
Toxicon

Short Communication
Delayed haemolytic activity by the freshwater puffer Tetraodon sp. toxin

https://doi.org/10.1016/S0041-0101(00)00197-5Get rights and content

Abstract

In order to elucidate the toxin composition of the freshwater puffer in Bangladesh, about 230 specimens of Tetraodon sp. were collected from 1997 to 1999 and extracted. After partitioning the toxins between an aqueous layer and a 1-butanol layer, the toxin in the aqueous layer was characterized as paralytic shellfish poison (PSP) (data not shown), while the toxin in the 1-butanol layer was identified as palytoxin (PTX) or PTX-like substance based on the delayed haemolytic activity which was inhibited by an anti-PTX antibody and ouabain (g-strophanthin). This is the first report on the occurrence of PTX or PTX-like substance(s) in puffer fish.

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Acknowledgements

We are grateful to Dr Lawrence Levine, Biochemistry Department, Brandeis University, USA for his generous help in supplying the PTX antibody.

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