Elsevier

Tetrahedron Letters

Volume 40, Issue 26, 25 June 1999, Pages 4833-4836
Tetrahedron Letters

Enantiomerically pure 1,2-bis(isopropylmethylphosphino)benzene and its use in highly enantioselective Rh-catalyzed asymmetric hydrogenation

https://doi.org/10.1016/S0040-4039(99)00856-4Get rights and content

Abstract

A new P-chiral phosphine ligand with a 1,2-phenylene unit, (S,S)-1,2-bis(isopropylmethylphosphino)benzene, has been synthesized from 1,2-bis(methylphosphino)benzene. Its rhodium complex is highly effective in asymmetric hydrogenation of dehydroamino acid methyl esters to provide enantioselectivities of up to 98%.

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