Elsevier

Tetrahedron Letters

Volume 43, Issue 25, 17 June 2002, Pages 4417-4420
Tetrahedron Letters

Utilization of lithium triethylborohydride as a selective N-acyl deprotecting agent

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Abstract

Lithium triethylborohydride has been found to be a superior and selective reagent for the removal of tertiary N-acyl protecting groups. The reagent selectively removes tertiary amide acyl functionality without affecting secondary amide functionality even when they are present in the same molecule. Some tertiary carbamates may be also removed under the same conditions.

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