Elsevier

Tetrahedron Letters

Volume 42, Issue 16, 16 April 2001, Pages 3041-3043
Tetrahedron Letters

Indium tribromide: a highly effective catalyst for the addition of trimethylsilyl cyanide to α-hetero-substituted ketones

https://doi.org/10.1016/S0040-4039(01)00368-9Get rights and content

Abstract

The catalytic addition of trimethylsilyl cyanide (TMSCN) to a large variety of hetero-substituted ketones promoted by anhydrous InBr3 has been studied. The low catalytic loading (0.1–1 mol%) and the mild experimental conditions required represent the key features of this novel catalytic system.

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Acknowledgments

The authors would like to thank CNR and MURST (Progetto Nazionale ‘Stereoselezione in Sintesi Organica: Metodologie ed Applicazioni’) and Bologna University (funds for selected research topics) for financial support of this research.

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