Original ArticlesAntibiotic susceptibility profile of group B streptococcus acquired vertically☆
Section snippets
Materials and methods
This investigation was conducted ancillary to an ongoing multicenter study, the major objective of which is to evaluate the pattern of the protective association between naturally acquired maternal serum group B streptococcus immunoglobulin G antibody titers and the risk of development of early onset neonatal group B streptococcus disease. The study was approved by the local Institutional Review Committee at the participating sites. As part of the overall study, separate neonatal surface
Results
The antibiotic susceptibility profiles of 119 colonizing and eight invasive strains of group B streptococcus were studied. These strains were isolated from 119 predominantly full-term, vaginally born neonates (Table 1 ). Results of the MIC determinations (Table 2 ) indicated that all colonizing strains were susceptible or moderately susceptible to ampicillin and penicillin G. Resistance was noted by at least one strain to each of the other antibiotics; all were resistant to gentamicin, whereas
Discussion
This investigation is unique in that only vertically acquired group B streptococcus isolates were subjected to susceptibility testing. Such isolates are, almost without exception, the only ones that can cause early onset group B streptococcus disease. Moreover, the isolates were obtained from hospitals in which the ACOG risk-factor–based approach1 to early onset neonatal group B streptococcus prevention had been used consistently for at least 3 years before the collection of the group B
References (10)
- American College of Obstetricians and Gynecologists. Prevention of early-onset group G streptococcal disease in...
- Centers for Disease Control and Prevention. Prevention of perinatal group B streptococcal disease: A public health...
- et al.
Antibiotic resistance patterns of group B streptococci in pregnant women
J Clin Microbiol
(1990) - et al.
Antibiotic resistance and penicillin tolerance in clinical isolates of group B streptococci
Antimicrob Agents Chemother
(1994) - et al.
Presumptive identification and antibiotic susceptibility of group B streptococci
Indian J Pathol Microbiol
(1994)
Cited by (42)
Are we using the optimal strategy for the management of group B streptococcal infection in pregnancy?
2006, Journal of Obstetrics and Gynaecology CanadaAre We Using the Optimal Strategy for GBS Management in Pregnancy?
2006, Journal of Obstetrics and Gynaecology CanadaNo increase in rates of early-onset neonatal sepsis by antibiotic-resistant group B Streptococcus in the era of intrapartum antibiotic prophylaxis
2005, American Journal of Obstetrics and GynecologyCitation Excerpt :In our study GBS isolates causing EONS remain susceptible to ampicillin, penicillin, cefazolin, and vancomycin over 13 years, consistent with other studies that investigated antibiotic resistance patterns in GBS isolates causing invasive disease over shorter time periods.13 Of note, 1 study did find 1% of GBS isolates resistant to cefazolin in neonates colonized with GBS.14 To our knowledge, ours is the first study to report the rate of erythromycin-resistant GBS EONS over time, and we have found no change.
The prevention of early-onset neonatal group B Streptococcal disease
2004, Journal of Obstetrics and Gynaecology CanadaThe Prevention of Early-Onset Neonatal Group B Streptococcal Disease
2004, Journal of Obstetrics and Gynaecology CanadaPredominance of serotype V and frequency of erythromycin resistance in Streptococcus agalactiae in Ohio
2003, American Journal of Obstetrics and Gynecology
- ☆
Supported in part by the Agency for Health Care Policy and Research Contract #290-92-0055 and National Institutes of Health Contract # N01 HD 4-3219.