Ultrastructure of rat ovarian interstitial cells. III. Response to luteinizing hormone

doi:10.1016/S0022-5320(76)80085-8

Journal of Ultrastructure Research

Volume 55, Issue 1, April 1976, Pages 96-104

https://doi.org/10.1016/S0022-5320(76)80085-8 Get rights and content

Administration of luteinizing hormone (LH) to rats which have been hypophysectomized for 6 weeks induces redifferentiation of regressed ovarian interstitial cells. At the ultrastructural level, this response involves nuclear and nucleolar hypertrophy, increases in cytoplasmic volume and number of ribosomes, and proliferation of the membranous systems of the cytoplasm. Restoration of abundant smooth endoplasmic reticulum and tubular mitochondrial cristae, characteristics of steroidogenic cells which are lost after hypophysectomy, are initiated within 6 hr by LH treatment. Only mitochondrial changes are continuous throughout the 72-hr observation period. Morphological responses to LH are prominent in these cytoplasmic structures before any change is discernible in nuclei, but nuclear hypertrophy, although delayed, is very rapid and is completed before cytoplasmic membranogenesis ceases.

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¹: This study was supported in part by Research Grant AM-05668 from the Institute of Arthritis and Metabolic Disease, N.I.H. and by a General Research Support Grant, College of Veterinary Medicine, Ames, Iowa.

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Ultrastructure of rat ovarian interstitial cells. III. Response to luteinizing hormone1

J. Ultrastruct. Res.

J. Ultrastruct.

Biochem. Biophys. Acta

Arch. Biochem.

J. Biol. Chem.

FEBS Lett.

Acta Endocr. (Kbh.)

Anat. Rec.

Biol. Reproduction