A model linking segmentation, compartmentalization and regeneration in Drosophila development

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Four important aspects of insect development, namely the establishment of the primary embryonic axes, the appearance of segments in the embryo, compartmentalization in imaginal discs during development, and regeneration of discs after experimental interference, have been the object of extensive investigation. To account for each phenomenon, an internally-consistent hypothesis has been formulated during the last few years. As yet, however, little attempt has been made to relate these four fields to each other. A model, based on the sequential establishment of a series of gradients whose function is to provide positional information to the cells and cause them to initiate defined developmental programmes, has been developed to account for the clonal restrictions that occur throughout development, for the way in which cells behave during regeneration, and for the action of a number of mutations.

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