Erythrocyte glucose-6-phosphate dehydrogenase activity in children with hypothyroidism and hypopituitarism*

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Erythrocyte glucose-6-phosphate dehydrogenase activity was measured in 9 children with hypothyroidism, and in 7 children with hypopituitarism. Pretreatment enzyme activities were well below normal in all children with hypothyroidism, and in 6 children with hypopituitarism. The administration of thyroid hormone was followed by increased enzyme activity in 5 of 5 subjects studied. The administration of human growth hormone was associated with increased enzyme activity in 4 of 6 patients after short-term administration, and in 2 of 2 subjects after long-term administration. Red cell G-6-PD activity was a sensitive index of the metabolic status of the patient.

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Cited by (5)

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    1976, Clinical Pediatrics
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Supported by United States Public Health Service Grants 2 T1 AM 5197 and AM 2231.

Portions of the studies were conducted in the Clinical Research Center, Children's Hospital of Philadelphia, supported by United States Public Health Service Grant 1 MO1 FR 00240.

Presented in part at the Society for Pediatric Research, Atlantic City, N. J., April 30, 1966 (1).

*

Address, 1740 Bainbridge St., Philadelphia, Pa. 19146.

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