Elsevier

Journal of Chromatography A

Volume 132, Issue 3, 21 February 1977, Pages 503-510
Journal of Chromatography A

High-pressure liquid chromatographic analysis of drugs in biological fluids: III. Analysis of disopyramide and its mono-n-dealkylated metabolite in Plasma and urine

https://doi.org/10.1016/S0021-9673(00)82914-3Get rights and content

Abstract

A high-pressure liquid chromatographic analysis for disopyramide (I) and its mono-N-dealkylated metabolite (II) in plasma and urine is described. The analysis, in which I and II together with an internal standard are chromatographed as ion pairs with heptanesulphonic acid, employs a simple and rapid method of sample preparation. The method is more sensitive, reproducible, and rapid than previously reported gas chromatographic methods.

References (6)

  • T.C. Hutsell et al.

    J. Chromatogr.

    (1975)
  • A.M.J.A. Duchateau et al.

    J. Chromatogr.

    (1975)
  • T.D. Bjornsson, T.F. Blaschke and P.J. Meffin, J. Pharm. Sci., in...
There are more references available in the full text version of this article.

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  • Drug level monitoring: cardiovascular drugs

    1985, Journal of Chromatography B: Biomedical Sciences and Applications
  • Disopyramide Phosphate

    1984, Analytical Profiles of Drug Substances and Excipients
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For Parts I and II of this series, see refs. 1 and 2.

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