The Fate of LSD in the Body: Forensic Considerations

doi:10.1016/S0015-7368(78)71189-8

Journal of the Forensic Science Society

Volume 18, Issues 1–2, January 1978, Pages 89-98

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The metabolism of LSD has been studied by analysing plasma and urine samples from Rhesus monkeys treated with radioactively labelled LSD. Plasma ¹⁴C radioactivity reached a maximum value within one hour after treatment and declined over the following 23 hours. The ¹⁴C radioactivity was detectable in the urine samples for up to 48 hours and fractionation by HPLC showed seven peaks of radioactivity, five of which cross-reacted in the RIA procedure.

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Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids
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Continued illicit use of the potent psychedelic drug lysergic acid diethylamide (LSD) has stimulated efforts to develop effective analytical methods for detection of the drug and its metabolites in body fluids from suspected LSD users. Recently reported methods based on gas and liquid chromatography, combined with single- and multiple-stage mass spectral analysis, now permit accurate detection and quantitation of LSD at sub-nanogram/milliliter concentrations.
The development and evaluation of a <sup>125</sup>I radioimmunoassay for the measurement of LSD in body fluids
1986, Forensic Science International
A radioimmunoassay (RIA) has been developed for the direct detection of LSD in biological fluids. The radiotracer, (+)-2-[¹²⁵I]iodo-LSD, allows the use of gamma-counting rather than the liquid scintillation counting currently used for existing ³H radioimmunoassays.
The assay is specific for LSD and very closely related compounds. It is inexpensive, sensitive, simple to use and small volumes of sample (50 μl) can be assayed directly without the need for any time-consuming extraction procedures. The cut-off levels are 1.2 ng/ml in blood and 3.0 ng/ml in urine.
The results obtained using the ¹²⁵I assay described in this work compare very favourably with those obtained using the ³H assay currently used by Home Office Forensic Science Laboratories. The advantages of the assay make it a most appropriate method for the routine screening of LSD in biological samples of forensic interest.
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Determination of lysergic acid diethylamide in body fluids by high- performance liquid chromatography and fluorescence detection - A more sensitive method suitable for routine use
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1998, Clinical Chemistry

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¹: Present address: Home Office Forensic Science Laboratory, Priory House, Gooch Street North, Birmingham, England B5 6QQ.

²: Author to whom correspondence should be addressed.

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The Fate of LSD in the Body: Forensic Considerations

J. Chromat.

Clin. Chim. Acta.

Clin. Pharmacol. Ther.

Ann. N. Y. Acad. Sci.

‘Drugs of Hallucination’

Arch. Neurol. Psychiat.

J. Chromatogr. Sci.