ReviewSelenium and immune responses
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Cited by (173)
Relationship between selenium status, selenoproteins and COVID-19 and other inflammatory diseases: A critical review
2023, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :The resolution of inflammation, which is necessary to reestablish cellular and organismal homeostasis, is mediated and regulated by various classes of chemical mediators, and the adequate (neither insufficient nor exaggerated) immune response to infectious agents requires a chronologically orchestrated interplay between pro- and anti-inflammatory mediators [47–53]. Adequate Se intake is crucial for the appropriate functioning of cellular and humoral immune processes (Table 1) [16,36,37,54–57]. For instance, the inclusion of sodium selenite in the diet of pigs (0.05–0.1 ppm) [58], lambs (1 ppm) [59], and mice (0.5 or 2 ppm) [60] has been shown to modulate the activity of adaptive immune response by stimulating the appropriate proliferation of T and B lymphocytes in response to mitogens [54], and by preventing the apoptosis of T lymphocytes and natural killer (NK) cells [54].
Immunotoxicology of metals
2021, Handbook on the Toxicology of Metals: Fifth EditionImmunotoxicology of metals
2021, Handbook on the Toxicology of Metals: Volume I: General ConsiderationsRoles for selenium and selenoprotein P in the development, progression, and prevention of intestinal disease
2018, Free Radical Biology and MedicineSelenium Supplementation, Antioxidant Effects, and Immune Restorative Effects in Human Immunodeficiency Virus
2018, HIV/AIDS: Oxidative Stress and Dietary AntioxidantsToxic elements and associations with hematology, plasma biochemistry, and protein electrophoresis in nesting loggerhead sea turtles (Caretta caretta) from Casey Key, Florida
2017, Environmental PollutionCitation Excerpt :Therefore, it was unexpected that selenium toxicity could be related to a suppression of the immune response (McKenzie et al., 1998). However, both selenium deficiency and selenium toxicity have been shown to result in impairments of the immune system (Kiremidjian-Schumacher and Stotzky, 1987). Komoroske et al. (2011) found that blood selenium concentrations were negatively correlated with total globulins.