A gas-liquid chromatographic method for the determination of butriptyline in serum

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  • 1.

    A gas-liquid chromatographic (GC) method for the analysis of butriptyline in serum has been developed. Quantitation is based on the peak height ratio between butriptyline and promazine used as internal standard. A triple partition provides a “clean” extract. A detection limit of 10 ng/ml is achieved.

  • 2.

    The usefulness of the method has been demonstrated in bioavailability studies in dogs.

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