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Br Homeopath J 1997; 86(02): 73-85
DOI: 10.1016/S0007-0785(97)80121-4
 
Copyright © The Faculty of Homeopathy 1997

The similia principle

From cellular models to regulation of homeostasis
Paulo Bellavite
,
Sabrina Lussignoli
,
Marlia Lucia Semizzi
,
Riccardo Ortolani
,
Andrea Signorini   *

Subject Editor:
Further Information

Publication History

Publication Date:
21 June 2018 (online)

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Abstract

We have developed two models of the similarity principle, essentially based on the regulatory mechanisms of biological homeostasis. A first model (gating theory) is designed to explain a series of experimental findings obtained in our laboratory, pointing to the occurrence of inverse effects of various agents on human neutrophils in vitro. A second, more general, model (regulation of stressed homeostatic networks) is designed to integrate modern concepts of priming, desensitization and signal transduction into the classical homeopathic theory of inversion of effect at the clinical level, i.e. the symptom-based similia principle.

Keywords

Similia principle - Homeostasis - Leukocytes - Receptors - Transduction systems - Gating theory - Stress - Inverse effects - Hormesis.

* Institute of Clinical Chemistry and Microscopy, University of Verona and Verona Homoeopathic Medical School.