Elsevier

Brain Research

Volume 845, Issue 1, 16 October 1999, Pages 107-111
Brain Research

Short communication
Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

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Abstract

The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage.

Keywords

Albumin
Global cerebral ischemia
Neuroprotection
Stroke

Cited by (0)

1

Present addresses: Catholic University Medical College, Uijonbu City, South Korea.

2

Present address: Universita di Pavia, Pavia, Italy.