BCP Symposium PresentationRole of Gadd45 in apoptosis
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2021, Science of the Total EnvironmentCitation Excerpt :In addition to the aforementioned effects on cell cycle arrest, gadd45 was shown to induce the G2/M phase cell cycle checkpoint (Vairapandi et al., 2002; Wang et al., 1999), which could support our deduction that A549 cells proceeded through S phase but accumulated at the checkpoint in G2 phase after TBOEP and TDCPP insults. Specifically, studies have indicated that gadd45β can inhibit Cdk1/cyclinB1 kinase activity in vitro and in vivo, bind the Cdk1/cyclinB1 complex under the action of genotoxic agents (Jin et al., 2000), and direct different stress response pathways (Liebermann and Hoffman, 2008; Sheikh et al., 2000; Wang et al., 1999). The results of the present study suggest that gadd45β functions in the p53/p21-mediated cell cycle pathway in response to PFR-induced oxidative stress.
Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)
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